Cellcyclecheckpointinhibitors

由 R Visconti 著作 · 2016 · 被引用 329 次 — Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA ...

2023年4月8日 — Abstract. Cell cycle checkpoint activation promotes DNA damage repair, which is highly associated with the chemoresistance of various cancers ...

由 T Vlatkovic 著作 · 2022 · 被引用 8 次 — Inhibiting one or more cell cycle checkpoints may cause cells carrying unrepaired DNA to divide, leading to increased genomic instability and ...

由 I Collins 著作 · 2005 · 被引用 290 次 — The discovery and development of cell cycle checkpoint kinase inhibitors has progressed at a slower rate than for the CDKs, but is now starting to catch up, in ...

Cells that are HRD may be particularly vulnerable to checkpoint inhibitors that prevent the cell cycle checkpoints from appropriately inducing cell arrest ...

Cell Cycle inhibitors used in various studies in vivo and in vitro, with complicated regulation mechanism, have been broadly applied to cancer patients.

由 S Hauge 著作 · 2023 · 被引用 14 次 — Inhibitors of WEE1, CHK1 and ATR cause abrogation of the G2 checkpoint. Normal cells can still arrest in G1 phase, repair the DNA damage and survive (left).